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Recurrent Pregnancy Loss > Testing > Lupus Anti-Coagulant > MTHFR Mutation MTHFR (Methylene Tetra-Hydro Folate Reductase) is an enzyme that is important in the conversion of homocysteine to methionine. High levels of homocysteine are toxic to both the individual and the fetus if pregnant, causing an increased risk of abnormal clotting. There are two genes that code for MTHFR. If both of these are abnormal,higher homocysteine levels can be found in the maternal serum and in the amniotic fluid. High dose supplementation with folic acid reduces the homocysteine level by enhancing the functioning of the enzyme. Mutations in MTHFR, are very frequent, occurring in almost half the population. One mutation typically does not casue problems, but two mutations can be problematic with high homocysteine levels. Again, this is easlity treated with additional folic acid supplementation.back © 2005 Jarrett Fertility Group |
